Already a member? Become a member Register
PCSK9 Forum

rss LinkedIn News
rss LinkedIn Latest News Updates

Anthony Wierzbicki Articles

Lipoprotein(a) – does it matter when LDL cholesterol is low?

Lipoprotein(a) – does it matter when LDL cholesterol is low?

Lipoprotein(a) is now recognised as an independent risk factor for cardiovascular disease. But is it also relevant to consider lipoprotein(a) when LDL cholesterol is low? Prof. Anthony S Wierzbicki, Guy’s and St Thomas’ Hospitals, London, UK discusses the evidence. Lipoprotein(a) [Lp(a)] is a well-characterised biomarker…

read more »
PSCK9 inhibitor therapy- after the clinical trials, what can we learn to improve practice?

PSCK9 inhibitor therapy- after the clinical trials, what can we learn to improve practice?

The major cardiovascular disease (CVD) outcomes trials with the antibody-based inhibitors of proprotein convertase subtilisin kexin type 9 (PCSK9) have now been completed. Both ODYSSEY Outcomes with alirocumab in patients with acute coronary syndromes (ACS) and FOURIER with evolocumab in patients with stable CVD, were…

read more »
Is a PCKS9 vaccine a possibility for the future?

Is a PCKS9 vaccine a possibility for the future?

PCSK9 Forum has previously reported on preliminary experimental data for a PCSK9 vaccine. A recent publication in The European Heart Journal provides more details, albeit in an experimental preclinical model. Researchers used the APOE*3Leiden.CETP mouse model, a well-established, translational mouse model for hyperlipidaemia and atherosclerosis,…

read more »
PlayWill CANTOS and REVEAL change how we view the clinical use of PCSK9 inhibitors?

Will CANTOS and REVEAL change how we view the clinical use of PCSK9 inhibitors?

Prof Anthony Wierzbicki, New Associate Editor of PCSK9 Forum discusses Atherosclerosis has long been recognised as a chronic inflammatory disease, where low-density lipoproteins (LDL) interact with both innate and adaptive immunity mechanisms. However, while inflammatory infiltration by circulating white blood cells is an important part…

read more »
Back to basics on cost-effectiveness

Back to basics on cost-effectiveness

Professor Anthony Wierzbicki (Guy’s & St Thomas’ Hospitals, London, UK) provides a back to basics on cost-effectiveness analyses. Specifically, he highlights the uses and abuses of cost-effectiveness and quality-adjusted life year analyses in determining access to novel treatments. One of the key questions in cost-effectiveness…

read more »
PlayCountdown to FOURIER: What are the implications for patients?

Countdown to FOURIER: What are the implications for patients?

Countdown to FOURIER: What are the implications for patients? PCSK9 Forum Editor Professor Anthony Wierzbicki gives his view.

read more »
PlayLooking to FOURIER: What do the trials tell us about LDL lowering and cardiovascular events?

Looking to FOURIER: What do the trials tell us about LDL lowering and cardiovascular events?

Presentation of full results from the FOURIER cardiovascular outcomes trial with the PCSK9 monoclonal antibody evolocumab is imminent. Here, PCSK9 Forum Editor Professor Anthony Wierzbicki (Guy’s and St Thomas’ NHS Foundation Trust, London UK) looks back over more than 25 years of trials of LDL…

read more »
PlayAnthony Wierzbicki, Guy’s & St Thomas’ Hospitals, London discusses the implications of key trials at AHA 2016

Anthony Wierzbicki, Guy’s & St Thomas’ Hospitals, London discusses the implications of key trials at AHA 2016

Anthony Wierzbicki, Guy’s & St Thomas’ Hospitals, London discusses the implications of key trials at AHA 2016 GLAGOV ORION

read more »
PlayHeart UK statement on homozygous familial hypercholesterolaemia places PCSK9 inhibitors as second‑line treatment

Heart UK statement on homozygous familial hypercholesterolaemia places PCSK9 inhibitors as second‑line treatment

Although homozygous familial hypercholesterolaemia (FH, inherited high cholesterol) is rare, the severity of the condition underlines the need for an aggressive approach to management. This statement from Heart UK has weighed up the evidence for all three treatment modalities – pharmacotherapy, lipoprotein apheresis and liver…

read more »
PCSK9 inhibitors: Who and when to treat?

PCSK9 inhibitors: Who and when to treat?

Professor Tony Wierzbicki (Guy’s & St Thomas’ Hospitals, London, UK) discusses considerations for the use of PCSK9 inhibitors from a policy maker perspective (NICE, National Institute for Health and Care Excellence in the UK). He raises issues about the data for each high risk patient…

read more »
Premium quality or just over-priced? How affordable are the PCSK9 monoclonal antibodies?

Premium quality or just over-priced? How affordable are the PCSK9 monoclonal antibodies?

Anthony Wierzbicki, Guy’s & St Thomas’ Hospitals, London discusses recent economic analyses from the US and UK. Cardiovascular disease (CVD) remains one of the commonest causes of morbidity and mortality in the world. The epidemiology of CVD is changing as rates of smoking decrease but…

read more »
PCSK9 therapy- the solution to all cardiovascular disease?

PCSK9 therapy- the solution to all cardiovascular disease?

Prof. Anthony S Wierzbicki, Department of Metabolic Medicine/Chemical Pathology, Guy’s & St Thomas’ Hospitals, London, UK discusses evidence from a number of meta-analyses of PCSK9 inhibitor treatment.  Cardiovascular disease (CVD) has multiple manifestations in different vascular beds and is driven by multiple CVD risk factors….

read more »
Lifetime exposure and primordial prevention

Lifetime exposure and primordial prevention

Atherosclerosis is a slow onset insidious disease. It is asymptomatic until its manifestations cause significant morbidity and mortality. There is no cheap easy way to detect it. As a result disease management strategies rely on epidemiologically-based risk calculators to identify individuals likely to have significant…

read more »
Enhancing and Improving cardiovascular outcomes

Enhancing and Improving cardiovascular outcomes

Implications from IMPROVE-IT: Perspective from Anthony S. Wierzbicki* The link between low density lipoprotein-cholesterol (LDL-C) and cardiovascular disease (CVD) is well established 1 3 . Statins are the first-line drug therapy for the treatment of lipid-associated CVD risk. However the role of second line therapies…

read more »
IMPROVE-IT: will it prove anything?

IMPROVE-IT: will it prove anything?

Professor Anthony S. Wierzbicki, London UK Comments on the IMPROVE-IT debate Cardiovascular disease (CVD) guidelines are emphasising the use of clinical outcome data on major vascular events (American Heart Association/American College of Cardiology)1 or hard CVD events alone (UK NICE)2 . They have begun to…

read more »
What does PCSK9 monoclonal antibody therapy offer to reduce residual CV risk?

What does PCSK9 monoclonal antibody therapy offer to reduce residual CV risk?

Anthony S. Wierzbicki DM, DPhil, FRCPath Consultant, Department of Metabolic Medicine/Chemical Pathology Guy’s & St Thomas’ Hospitals St Thomas’ Hospital, London UK E-mail: Anthony.Wierzbicki@kcl.ac.uk Cardiovascular disease (CVD) remains the greatest cause of world morbidity and mortality. Rates of CVD have decreased in parallel with reductions…

read more »