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News from FOURIER: Benefit with evolocumab across all vascular territories

News from FOURIER: Benefit with evolocumab across all vascular territories

In this latest analysis from the FOURIER trial, treatment with evolocumab reduced acute arterial events in coronary, cerebro- and peripheral vascular territories with a robust effect over time. FOURIER (Further Cardiovascular OUtcomes Research With PCSK9 Inhibition in Subjects with Elevated Risk) was a landmark trial…

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More insights from ORION

More insights from ORION

News from AHA Scientific Sessions 2021 Baseline glycaemic status or body mass index (BMI) did not impact the efficacy of inclisiran, according to two post hoc analyses of the ORION trials. The first poster presentation reported findings from a post hoc analysis of the ORION-10…

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Long-term evinacumab in homozygous FH

Long-term evinacumab in homozygous FH

News from AHA Scientific Sessions 2021 Evinacumab was the focus of two presentations in patients with homozygous familial hypercholesterolaemia (FH, inherited high cholesterol). Homozygous FH is a rare genetic lipid disorder, which is characterized by markedly elevated low-density lipoprotein (LDL) cholesterol levels from birth and…

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Combination alirocumab-evinacumab in homozygous FH

Combination alirocumab-evinacumab in homozygous FH

News from AHA Scientific Sessions 2021 Combination treatment with alirocumab plus the angiopoietin-like 3 (ANGPTL3) inhibitor evinacumab, on top of lipid lowering therapy, reduced LDL cholesterol levels by more than 60%, according to a post hoc analysis presented at AHA Scientific Sessions. This report analysed…

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MK-0616: Hope for an oral PCSK9 inhibitor?

MK-0616: Hope for an oral PCSK9 inhibitor?

News from AHA Scientific Sessions 2021 A novel oral PCSK9 inhibitor, MK-0616, showed substantial reduction in LDL cholesterol levels and was generally well tolerated, according to early trial data. Current PCSK9-directed therapies are undoubtedly effective in lowering LDL cholesterol, against a background of statin-ezetimibe therapy….

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Lipid news from the poster sessions

Lipid news from the poster sessions

News from ESC Congress 2021 (Virtual) How common is statin intolerance? The latest findings from a worldwide systematic review and meta-analysis including over 4 million patients indicates a low prevalence of statin intolerance, especially when assessed objectively using recognized international criteria. In this report, the…

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PCSK9-NATURE vindicates targeting LDL cholesterol reduction earlier rather than later

PCSK9-NATURE vindicates targeting LDL cholesterol reduction earlier rather than later

News from ESC Congress 2021 (Virtual) Earlier reduction in LDL cholesterol provides greater lifelong cardiovascular benefit, according to results of PCSK9-NATURE (NATUrally Randomized ‘target’ trial Evaluating a yearly vaccine-like strategy to lower LDL by inhibiting PCSK9 on the lifetime risk of major coronary events), presented…

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Inclisiran effective in patients with polyvascular and cerebrovascular disease

Inclisiran effective in patients with polyvascular and cerebrovascular disease

News from ESC Congress 2021 (Virtual). The ESC Congress 2021 featured news from the ORION trials, with subgroup analyses evaluating the efficacy of inclisiran in patients with polyvascular disease (PVD) or cerebrovascular disease. PVD is a particularly malignant atherosclerotic cardiovascular disease (ASCVD) associated with an…

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UK NICE approves use of inclisiran: a gamechanger for patients and the NHS

UK NICE approves use of inclisiran: a gamechanger for patients and the NHS

The siRNA inclisiran is approved by the UK National Institute for Health and Care Excellence (NICE) for use in primary care in England. Inclisiran (Leqvio®), given as a twice-yearly injection, is recommended for people with primary hypercholesterolaemia or mixed dyslipidaemia who have had a previous…

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HUYGENS reinforces the importance of intensive lipid lowering after ACS

HUYGENS reinforces the importance of intensive lipid lowering after ACS

News from ESC Congress 2021 (Virtual). Lowering LDL cholesterol indisputably reduces cardiovascular events (1). The landmark PCSK9 inhibitor trials demonstrated that incremental lowering of LDL cholesterol against a background of intense statin therapy further reduced cardiovascular events, with no apparent threshold for clinical benefit from…

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No effect on cognitive function with alirocumab

No effect on cognitive function with alirocumab

Treatment with alirocumab for up to 96 weeks had no affect on cognitive function, assessed using the CANTAB (Cambridge Neuropsychological Test Automated Battery) scale, in this study of over 2,000 patients at increased cardiovascular risk (1). PCSK9 monoclonal antibody therapy is highly efficacious in lowering…

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More from FOURIER: Evolocumab effective in Asian patients

More from FOURIER: Evolocumab effective in Asian patients

A new analysis from the FOURIER (Further Cardiovascular OUtcomes Research With PCSK9 Inhibition in Subjects with Elevated Risk) trial showed that evolocumab was equally effective in lowering the risk of cardiovascular events in Asian and non-Asian patients (1). FOURIER demonstrated that lowering LDL cholesterol levels…

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PlayAre very low lipoprotein(a) levels safe? Insights from the Copenhagen General Population Study

Are very low lipoprotein(a) levels safe? Insights from the Copenhagen General Population Study

High lipoprotein(a) levels are clearly established as a risk factor for cardiovascular disease and aortic valve stenosis (1,2). Recent lipid guidelines have affirmed the importance of measuring lipoprotein(a) [Lp(a)] in individuals with intermediate risk or with a family or personal history of premature or recurrent…

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PlayWhich lipid markers best identify residual risk in statin-treated patients?

Which lipid markers best identify residual risk in statin-treated patients?

LDL cholesterol is undoubtedly the priority lipid target to prevent atherosclerotic cardiovascular disease. Yet even with attainment of very low levels, high risk patients continue to experience cardiovascular events. The question is: which is the best lipid to target this residual risk? The options include…

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Treating high risk cardiovascular disease: Is combination lipid lowering therapy now the rule not the exception?

Treating high risk cardiovascular disease: Is combination lipid lowering therapy now the rule not the exception?

In 2019 the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) updated their guidelines for the management of dyslipidaemia to prevent atherosclerotic cardiovascular disease (ASCVD). On the basis of evidence from IMPROVE-IT with ezetimibe and the two landmark PCSK9 inhibitor trials, FOURIER with…

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HUYGENS: How does PCSK9 inhibition impact plaque phenotype?

HUYGENS: How does PCSK9 inhibition impact plaque phenotype?

Randomized controlled trials have unequivocally established that lowering levels of low-density lipoprotein (LDL) cholesterol reduces cardiovascular event rates in both the primary and secondary prevention setting (1).  Moreover, there is no apparent threshold to benefit, as demonstrated in landmark cardiovascular outcomes studies with PCSK9 monoclonal…

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Pooled analysis highlights the promise of inclisiran

Pooled analysis highlights the promise of inclisiran

A new pooled analysis shows that inclisiran, twice yearly in addition to statin, is effective and safe in patients with or at high risk of atherosclerotic cardiovascular disease (ASCVD) (1). Low-density lipoprotein (LDL) cholesterol is established as causal for ASCVD (2,3). While statins are undoubtedly…

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News from ODYSSEY OUTCOMES: Lipoprotein(a) and diabetes risk

News from ODYSSEY OUTCOMES: Lipoprotein(a) and diabetes risk

A new analysis from the ODYSSEY OUTCOMES study reports that lower lipoprotein(a) concentration is associated with increased risk for incident type 2 diabetes in patients with acute coronary syndrome (1). Beyond efficacious LDL cholesterol lowering, PCSK9 inhibitors also reduce lipoprotein(a) [Lp(a)], a highly heritable risk…

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EUROASPIRE: Need to improve risk factor management in women with diabetes and CAD

EUROASPIRE: Need to improve risk factor management in women with diabetes and CAD

More needs to be done to improve risk factor management in women with dysglycaemia and coronary artery disease (CAD), according to findings from this survey within the European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) IV and V framework (1)….

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LDL cholesterol management inferior in women in primary care

LDL cholesterol management inferior in women in primary care

In both primary and secondary prevention settings, management of LDL cholesterol is worse in women than men, according to this Swiss study in over 50,000 patients. It is well recognised that there are disparities between men and women in cardiovascular disease (CVD) prevention. While premenopausal…

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