Expert views and opinion
International experts discuss hot topics in the modern management of patients with dyslipidaemia.
Topics include:
- Cholesterol metabolism
- The role of PCSK9 in lipid metabolism
- Modern diagnosis and management of familial hypercholesterolaemia around the world
- Recent trials
- Key messages from international congresses
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Lerodalcibep: What does LIBerate-HeFH tell us?](https://img.youtube.com/vi//0.jpg)
Frederick J. Raal
Lerodalcibep: What does LIBerate-HeFH tell us?
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![Verve-101: Where are we up to with PCSK9 gene editing?](https://img.youtube.com/vi//0.jpg)
Steve Humphries
Verve-101: Where are we up to with PCSK9 gene editing?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Apo(a) size and PAD revascularisation outcomes: What’s the link?](https://img.youtube.com/vi//0.jpg)
Marianna Pavlyha
Apo(a) size and PAD revascularisation outcomes: What’s the link?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Lepodisiran: What progress towards Lp(a) reduction?](https://img.youtube.com/vi//0.jpg)
Steve Nissen
Lepodisiran: What progress towards Lp(a) reduction?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![What’s new on the horizon for lipoprotein(a) therapies?](https://img.youtube.com/vi/QRIjv_q2sRU/0.jpg)
Henry Ginsberg
What’s new on the horizon for lipoprotein(a) therapies?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Should ACS patients start a PCSK9 inhibitor in hospital?](https://img.youtube.com/vi/3gPlE4d5atU/0.jpg)
Steve Nicholls
Should ACS patients start a PCSK9 inhibitor in hospital?
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![APOLLO trial with SLN360](https://img.youtube.com/vi/NVCsWukIlVo/0.jpg)
Steve Nicholls
APOLLO trial with SLN360
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![What can we learn from the Homozygous Familial Hypercholesterolaemia International Clinical Collaboration registry?](https://img.youtube.com/vi/8IjYQ6RJyiE/0.jpg)
Tycho Tromp
What can we learn from the Homozygous Familial Hypercholesterolaemia International Clinical Collaboration registry?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![What does the future hold for CRISPR base editing of PCSK9?](https://img.youtube.com/vi/8dIUSRl2zD4/0.jpg)
Kiran Musunuru
What does the future hold for CRISPR base editing of PCSK9?
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![ESC 2021 Inclisiran in polyvascular disease](https://img.youtube.com/vi/1afdrSMPv4M/0.jpg)
Frederick J. Raal
ESC 2021 Inclisiran in polyvascular disease
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Huygens: Does PCSK9 inhibition impact the vulnerable plaque?](https://img.youtube.com/vi/jH6aRQTBzZw/0.jpg)
Steve Nicholls
Huygens: Does PCSK9 inhibition impact the vulnerable plaque?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![LDL cholesterol lowering and effects on plaque: what can we learn from INTENSITY-HIGH?](https://img.youtube.com/vi/iU9WpjyqlJ4/0.jpg)
John Chapman
LDL cholesterol lowering and effects on plaque: what can we learn from INTENSITY-HIGH?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Why should clinical practice move to an intensive LDL-C lowering approach?](https://img.youtube.com/vi/4gnba4k-Dm4/0.jpg)
Chris Packard
Why should clinical practice move to an intensive LDL-C lowering approach?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![How do clinicians translate intensive LDL-C lowering to their practice?](https://img.youtube.com/vi/0n1kOhQdQXA/0.jpg)
Chris Packard
How do clinicians translate intensive LDL-C lowering to their practice?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Are very low lipoprotein(a) levels safe? Insights from the Copenhagen General Population Study](https://img.youtube.com/vi/FkR_wMTRptI/0.jpg)
Are very low lipoprotein(a) levels safe? Insights from the Copenhagen General Population Study
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Which lipid markers best identify residual risk in statin-treated patients?](https://img.youtube.com/vi/-wBvcX2ZZ5w/0.jpg)
Which lipid markers best identify residual risk in statin-treated patients?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Very low lipoprotein(a) and very low LDL cholesterol – are they safe?](https://img.youtube.com/vi/xOVtsl3nL8E/0.jpg)
Chris Packard
Very low lipoprotein(a) and very low LDL cholesterol – are they safe?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Combination therapy in familial hypercholesterolaemia: what can we gain from novel agents?](https://img.youtube.com/vi/skjKMB0PJRk/0.jpg)
Frederick J. Raal
Combination therapy in familial hypercholesterolaemia: what can we gain from novel agents?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Triglyceride lowering and residual risk: what can we learn from the trials?](https://img.youtube.com/vi/zhpaXrCpz-4/0.jpg)
Steve Nicholls
Triglyceride lowering and residual risk: what can we learn from the trials?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: GPs in FH care](https://img.youtube.com/vi/ZAywLQA_vvE/0.jpg)
VIDEO: GPs in FH care
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: New FH guidance for Australasia](https://img.youtube.com/vi/S34pd4nl3uA/0.jpg)
VIDEO: New FH guidance for Australasia
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: The SAMSON Study](https://img.youtube.com/vi/K_il-nbe4GM/0.jpg)
VIDEO: The SAMSON Study
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![VIDEO: Evinacumab in refractory hypercholesterolaemia](https://img.youtube.com/vi/KmWssuwlnXc/0.jpg)
VIDEO: Evinacumab in refractory hypercholesterolaemia
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Steve Nicholls discusses STRENGTH](https://img.youtube.com/vi/vJxLzvMmgWY/0.jpg)
Steve Nicholls
VIDEO: Prof Steve Nicholls discusses STRENGTH
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Steve Nicholls fish oils and AF](https://img.youtube.com/vi/zQuBNWq4qpM/0.jpg)
Steve Nicholls
VIDEO: Prof Steve Nicholls fish oils and AF
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Do we treat high LDL-C in the ‘healthy’ elderly?](https://img.youtube.com/vi/_kL728uuUiY/0.jpg)
VIDEO: Do we treat high LDL-C in the ‘healthy’ elderly?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Professor Santos discusses HAUSER-RCT](https://img.youtube.com/vi/Dce1nluuYCg/0.jpg)
Raul Santos
Professor Santos discusses HAUSER-RCT
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![VIDEO: Prof PG Steg Targeting PCSK9 inhibition](https://img.youtube.com/vi/N54fzKESUbQ/0.jpg)
VIDEO: Prof PG Steg Targeting PCSK9 inhibition
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Greg Schwartz Candidates for PCSK9 inhibition](https://img.youtube.com/vi/QlHLvB1NTDU/0.jpg)
VIDEO: Prof Greg Schwartz Candidates for PCSK9 inhibition
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Eric Bruckert EAS FHSC Registry](https://img.youtube.com/vi/yjzaPECq6pM/0.jpg)
VIDEO: Prof Eric Bruckert EAS FHSC Registry
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Eric Bruckert LDL goals in FH](https://img.youtube.com/vi/b-NiWI3qE-4/0.jpg)
VIDEO: Prof Eric Bruckert LDL goals in FH
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![VIDEO: Prof Raul Santos discusses the EAS FHSC Global Registry](https://img.youtube.com/vi/GUEuLhZ9HSk/0.jpg)
VIDEO: Prof Raul Santos discusses the EAS FHSC Global Registry
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![VIDEO: Professor Gregory Schwartz on the USA versus European lipid guidelines](https://img.youtube.com/vi/R5CAjFM0Jc0/0.jpg)
VIDEO: Professor Gregory Schwartz on the USA versus European lipid guidelines
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![VIDEO: Dr Robert Giugliano discusses the lipid guidelines](https://img.youtube.com/vi/96bcsuQTTpw/0.jpg)
VIDEO: Dr Robert Giugliano discusses the lipid guidelines
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Key messages from the 2019 ESC EAS dyslipidaemia guidelines](https://img.youtube.com/vi/J3Y-sHz3VOU/0.jpg)
VIDEO: Key messages from the 2019 ESC EAS dyslipidaemia guidelines
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: ORION 11](https://img.youtube.com/vi/Mbp5Md5C3-c/0.jpg)
VIDEO: ORION 11
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: EVOPACS evolocumab in the acute ACS setting](https://img.youtube.com/vi/ljjHJ_VkYr4/0.jpg)
VIDEO: EVOPACS evolocumab in the acute ACS setting
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: 2019 ESC EAS Dyslipidaemia Guidelines](https://img.youtube.com/vi/T2Lq7dSvkLc/0.jpg)
VIDEO: 2019 ESC EAS Dyslipidaemia Guidelines
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![VIDEO: Very low LDL C levels in ODYSSEY OUTCOMES](https://img.youtube.com/vi/blLESvfjA0g/0.jpg)
VIDEO: Very low LDL C levels in ODYSSEY OUTCOMES
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Real world use of evolocumab in FH](https://img.youtube.com/vi/1E3zv_wPRLQ/0.jpg)
VIDEO: Real world use of evolocumab in FH
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Stephen Nicholls Targeting PCSK9 inhibitors to the right patient](https://img.youtube.com/vi/BX_EGhaCpWk/0.jpg)
Steve Nicholls
VIDEO: Prof Stephen Nicholls Targeting PCSK9 inhibitors to the right patient
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Prof Stephen Nicholls Effect of alirocumab on MI types](https://img.youtube.com/vi/98xfRaPZ4cs/0.jpg)
Steve Nicholls
VIDEO: Prof Stephen Nicholls Effect of alirocumab on MI types
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Novel PCSK9 therapeutics](https://img.youtube.com/vi/pWf91o9w5p0/0.jpg)
VIDEO: Novel PCSK9 therapeutics
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: BANTING study in type 2 diabetes: evolocumab improves lipid goals and postprandial lipids](https://img.youtube.com/vi/ilJCCVLT3fw/0.jpg)
VIDEO: BANTING study in type 2 diabetes: evolocumab improves lipid goals and postprandial lipids
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: AHA/ACC 2018 Cholesterol Guidelines also have good points](https://img.youtube.com/vi/1ilM14AFUtA/0.jpg)
VIDEO: AHA/ACC 2018 Cholesterol Guidelines also have good points
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Coronary artery calcium for stratifying risk in familial hypercholesterolaemia](https://img.youtube.com/vi/n8kbWTAJXdE/0.jpg)
VIDEO: Coronary artery calcium for stratifying risk in familial hypercholesterolaemia
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: PCSK9 Forum Inhibitors and Health Economics](https://img.youtube.com/vi/aAspemFkMeY/0.jpg)
VIDEO: PCSK9 Forum Inhibitors and Health Economics
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![VIDEO: Perspective on the ODYSSEY OUTCOMES Economic Study](https://img.youtube.com/vi/3Qo70JwLdWI/0.jpg)
Gregory G. Schwartz
VIDEO: Perspective on the ODYSSEY OUTCOMES Economic Study
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: New insights from ODYSSEY OUTCOMES](https://img.youtube.com/vi/pzsNsiYIxPU/0.jpg)
Gregory G. Schwartz
VIDEO: New insights from ODYSSEY OUTCOMES
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: PCSK9 Forum Editor Professor John Chapman gives his take home messages about lipoprotein(a)](https://img.youtube.com/vi/YtksqRVZd-8/0.jpg)
John Chapman
VIDEO: PCSK9 Forum Editor Professor John Chapman gives his take home messages about lipoprotein(a)
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Why we need to avoid recurrent events: Plaque biology considerations](https://img.youtube.com/vi/c8Kbc5UIPN0/0.jpg)
VIDEO: Why we need to avoid recurrent events: Plaque biology considerations
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![REDUCE-IT- does the formulation matter?](https://img.youtube.com/vi/KnMRrQdSqBU/0.jpg)
REDUCE-IT- does the formulation matter?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![REDUCE-IT take home messages](https://img.youtube.com/vi/Q51wq8OzA6E/0.jpg)
REDUCE-IT take home messages
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![More guideline controversy](https://img.youtube.com/vi/PnSQvNiRzJw/0.jpg)
More guideline controversy
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Are we ready to test the lipoprotein(a) hypothesis](https://img.youtube.com/vi/Lfjunoa1ZwE/0.jpg)
Are we ready to test the lipoprotein(a) hypothesis
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![AHA 2018 ODYSSEY Alternative Extension Trial](https://img.youtube.com/vi/5jTHN527_1I/0.jpg)
AHA 2018 ODYSSEY Alternative Extension Trial
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![VIDEO: AHA 18 ODYSSEY OUTCOMES Take Home Messages from Total Events Analysis](https://img.youtube.com/vi/0tAXTLo60bM/0.jpg)
VIDEO: AHA 18 ODYSSEY OUTCOMES Take Home Messages from Total Events Analysis
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![AHA 2018 ODYSSEY OUTCOMES Total Events Analysis](https://img.youtube.com/vi/wd5lGIHnLMY/0.jpg)
AHA 2018 ODYSSEY OUTCOMES Total Events Analysis
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: AHA 2018 US Cholesterol Guidelines](https://img.youtube.com/vi/9AonzOE2DAo/0.jpg)
VIDEO: AHA 2018 US Cholesterol Guidelines
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![Dr Brian Ference sets the record straight on questions about benefit in FOURIER](https://img.youtube.com/vi/_xUqj4rc5Xk/0.jpg)
Dr Brian Ference sets the record straight on questions about benefit in FOURIER
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![FOURIER update: new impetus for guideline groups to reconsider LDL targets](https://img.youtube.com/vi/pJQ0AfccX1g/0.jpg)
FOURIER update: new impetus for guideline groups to reconsider LDL targets
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![Is lowering lipoprotein(a) beneficial when LDL-C is very low?](https://img.youtube.com/vi/iUn-AVlgOeU/0.jpg)
Is lowering lipoprotein(a) beneficial when LDL-C is very low?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: How best to optimise PCSK9 inhibition, considering findings from FOURIER and ODYSSEY Outcomes](https://img.youtube.com/vi/GCLLQHGnWlo/0.jpg)
VIDEO: How best to optimise PCSK9 inhibition, considering findings from FOURIER and ODYSSEY Outcomes
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![VIDEO: What’s in the PCSK9 pipeline?](https://img.youtube.com/vi/tRiC138bgU0/0.jpg)
VIDEO: What’s in the PCSK9 pipeline?
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![VIDEO: EAS Congress: Lowering lipoprotein(a) for clinical benefit: How much?](https://img.youtube.com/vi/xbgKFGRJqP0/0.jpg)
VIDEO: EAS Congress: Lowering lipoprotein(a) for clinical benefit: How much?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![EAS Consensus Panel: Statins do not impair cognitive function](https://img.youtube.com/vi/OMf_Z25oTu4/0.jpg)
EAS Consensus Panel: Statins do not impair cognitive function
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![EAS Congress: FOURIER analysis shows benefit of PCSK9 inhibition in patients with elevated lipoprotein(a)](https://img.youtube.com/vi/u9FfYvFyOnk/0.jpg)
EAS Congress: FOURIER analysis shows benefit of PCSK9 inhibition in patients with elevated lipoprotein(a)
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![The Word from ACC 2018: ODYSSEY Outcomes](https://img.youtube.com/vi/gW1KWFy8bQQ/0.jpg)
The Word from ACC 2018: ODYSSEY Outcomes
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![Highlights from ACC.2018: Poster presentations](https://img.youtube.com/vi/xdNCWwG5ZZw/0.jpg)
Highlights from ACC.2018: Poster presentations
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![VIDEO: Will the trial evidence now overcome barriers to the use of PCSK9 inhibition?](https://img.youtube.com/vi/PlJWcpxdKmU/0.jpg)
Kausik Ray
VIDEO: Will the trial evidence now overcome barriers to the use of PCSK9 inhibition?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Will FOURIER and ODYSSEY Outcomes change LDL cholesterol goals in high-risk patients?](https://img.youtube.com/vi/JzIw8u5zX4U/0.jpg)
Steve Nicholls
Will FOURIER and ODYSSEY Outcomes change LDL cholesterol goals in high-risk patients?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![VIDEO: Do FOURIER and ODYSSEY Outcomes align with the ESC/EAS Task Force guidance on practical use of PCSK9 inhibition?](https://img.youtube.com/vi/UCpdXoN8Lzk/0.jpg)
Ulf Landmesser
VIDEO: Do FOURIER and ODYSSEY Outcomes align with the ESC/EAS Task Force guidance on practical use of PCSK9 inhibition?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Professor Stephen Nicholls (South Australian Health and Medical Research Institute, Adelaide, Australia): How do you interpret the mortality data from ODYSSEY Outcomes?](https://img.youtube.com/vi/3fNNF-wqmZA/0.jpg)
Steve Nicholls
Professor Stephen Nicholls (South Australian Health and Medical Research Institute, Adelaide, Australia): How do you interpret the mortality data from ODYSSEY Outcomes?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Professor Stephen Nicholls (South Australian Health and Medical Research Institute, Adelaide, Australia): Would you have expected a greater magnitude of benefit for the primary outcome in ODYSSEY Outcomes?](https://img.youtube.com/vi/gFJDzQgV7rU/0.jpg)
Steve Nicholls
Professor Stephen Nicholls (South Australian Health and Medical Research Institute, Adelaide, Australia): Would you have expected a greater magnitude of benefit for the primary outcome in ODYSSEY Outcomes?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Professor Raul Santos (University of São Paulo, Brazil): Why was the mortality benefit in ODYSSEY Outcomes only evident after 1 year of follow-up?](https://img.youtube.com/vi/Z8JZMNkt0qU/0.jpg)
Raul Santos
Professor Raul Santos (University of São Paulo, Brazil): Why was the mortality benefit in ODYSSEY Outcomes only evident after 1 year of follow-up?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Professor Raul Santos (University of São Paulo, Brazil): What are the key take home messages from ODYSSEY Outcomes?](https://img.youtube.com/vi/zmJcyZXIeJ8/0.jpg)
Raul Santos
Professor Raul Santos (University of São Paulo, Brazil): What are the key take home messages from ODYSSEY Outcomes?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Will ODYSSEY Outcomes change the management of ACS patients?](https://img.youtube.com/vi/Zx6B8w5UWWU/0.jpg)
Raul Santos
Will ODYSSEY Outcomes change the management of ACS patients?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![What is the take home message from ODYSSEY Outcomes regarding the role of LDL cholesterol in CVD prevention?](https://img.youtube.com/vi/1VOB3lENDn4/0.jpg)
Lluís Masana
What is the take home message from ODYSSEY Outcomes regarding the role of LDL cholesterol in CVD prevention?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![How do you explain the different mortality results in ODYSSEY Outcomes versus FOURIER?](https://img.youtube.com/vi/YH6f76iyy5c/0.jpg)
Francois Mach
How do you explain the different mortality results in ODYSSEY Outcomes versus FOURIER?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Does ODYSSEY Outcomes align with FOURIER and the SPIRE cardiovascular outcomes studies?](https://img.youtube.com/vi/9qZwoXXi70Q/0.jpg)
Steve Nicholls
Does ODYSSEY Outcomes align with FOURIER and the SPIRE cardiovascular outcomes studies?
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Prof John Chapman discusses safety data from the ODYSSEY Outcomes study](https://img.youtube.com/vi/L841zRYhW-I/0.jpg)
Prof John Chapman discusses safety data from the ODYSSEY Outcomes study
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Prof Henry Ginsberg discusses the ODYSSEY Outcomes topline data](https://img.youtube.com/vi/Cw8hxdFcagw/0.jpg)
Prof Henry Ginsberg discusses the ODYSSEY Outcomes topline data
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
![Prof Greg Schwartz Clinical implications of ODYSSEY Outcomes](https://img.youtube.com/vi/UjppuXxoUmA/0.jpg)
Prof Greg Schwartz Clinical implications of ODYSSEY Outcomes
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![Prof Greg Schwartz Key results of ODYSSEY Outcomes](https://img.youtube.com/vi/fp6BcjBYotg/0.jpg)
Prof Greg Schwartz Key results of ODYSSEY Outcomes
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![Prof Greg Schwartz Rationale and design of ODYSSEY Outcomes](https://img.youtube.com/vi/42OahIShghg/0.jpg)
Prof Greg Schwartz Rationale and design of ODYSSEY Outcomes
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![WOSCOPS analysis: Take home messages for clinicians](https://img.youtube.com/vi/8hMgBOD7Fw8/0.jpg)
WOSCOPS analysis: Take home messages for clinicians
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![Implications from the WOSCOPS analysis](https://img.youtube.com/vi/DoZQyC4fPd8/0.jpg)
Implications from the WOSCOPS analysis
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Ulf Landmesser
ESC/EAS Task Force issues updated clinical guidance for PCSK9 inhibitors
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Frederick J. Raal
Treatment with evolocumab avoids the use of lipoprotein apheresis in high risk patients
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Bertrand Cariou
ORION-1: inclisiran shows sustained LDL cholesterol lowering with 2 doses
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![TAUSSIG: Evolocumab shows benefit in children with homozygous familial hypercholesterolaemia](https://img.youtube.com/vi/MNOAhPMpp0Q/0.jpg)
TAUSSIG: Evolocumab shows benefit in children with homozygous familial hypercholesterolaemia
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Anthony Wierzbicki
Will CANTOS and REVEAL change how we view the clinical use of PCSK9 inhibitors?
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John Chapman
VIDEO: Implications of very low LDL cholesterol levels
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How does statin intolerance impact on clinical outcome?
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How to diagnose statin intolerance?
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Peter Lansberg
Dr Peter Lansberg: What does FOURIER mean for FH patients?
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John Chapman
The Word from ACC 2017 – Implications for Practice
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John Chapman
The Word from ACC 2017 – Key Results
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VIDEO: Access to PCSK9 inhibitor treatment: NLA survey provides important pointers
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Henry Ginsberg
John Chapman
FOURIER in the Hot Seat: What are the Implications for practice and access?
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Brian Ference
Dr Brian Ference sets the record straight on questions about benefit in FOURIER
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Evan Stein
Events are the driver in PCSK9 cardiovascular outcomes trials
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Evan Stein
Prof Evan Stein: What are the key messages from FOURIER?
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Ulf Landmesser
Prof Ulf Landmesser: How can we ensure the best value from PCSK9 inhibitor therapy?
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Steve Nicholls
Prof Steve Nicholls: How can FOURIER improve our clinical practice?
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Ulf Landmesser
Prof Ulf Landmesser: How will FOURIER impact practice?
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![Prof Steve Nicholls: Is there a link between the benefit of evolocumab observed in GLAGOV & FOURIER?](https://img.youtube.com/vi/BwhNJVpCgPA/0.jpg)
Steve Nicholls
Prof Steve Nicholls: Is there a link between the benefit of evolocumab observed in GLAGOV & FOURIER?
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Steve Nicholls
Prof Steve Nicholls: Is FOURIER a game changer?
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Prof Robert Rosenson: REGARDS study adds to EBBINGHAUS reassures on lack of effect on neurocognition at low LDL-C
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Raul Santos
VIDEO: Prof Raul Santos: How can PCSK9 monoclonal antibody therapy be cost effective?
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Francois Mach
Prof Francois Mach: How will FOURIER impact guidelines
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Francois Mach
Prof Francois Mach discusses EBBINGHAUS
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Raul Santos
Prof Raul Santos: Do PCSK9 inhibitors have adverse effects on neurocognition
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Henry Ginsberg
Prof Henry Ginsberg: Data needed on the diabetes subgroup in FOURIER
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Raul Santos
Prof Raul Santos: SPIRE trials with bococizumab
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Philip Barter
Prof Philip Barter: How do we translate the FOURIER data to clinical practice?
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John Chapman
Prof John Chapman: FOURIER – Why was there no significant effect on CV mortality?
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John Chapman
Prof John Chapman: FOURIER endpoint data
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Philip Barter
PCSK9 Forum Editor Professor Philip Barter discusses FOURIER
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Philip Barter
Take home message on FOURIER
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Henry Ginsberg
PCSK9 Forum Editor Professor Henry Ginsberg discusses FOURIER
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Anthony Wierzbicki
Countdown to FOURIER: What are the implications for patients?
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Philip Barter
Could PCSK9 inhibitors be used in FH children?
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Anthony Wierzbicki
Looking to FOURIER: What do the trials tell us about LDL lowering and cardiovascular events?
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John Chapman
Looking back at 2016: What made the news?
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PCSK9 inhibitors: cardiovascular benefit vs. diabetes risk
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Anthony Wierzbicki
Anthony Wierzbicki, Guy’s & St Thomas’ Hospitals, London discusses the implications of key trials at AHA 2016
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Anthony Wierzbicki
Heart UK statement on homozygous familial hypercholesterolaemia places PCSK9 inhibitors as second‑line treatment
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Raul Santos
SAFEHEART: Consider more than coronary complications in FH
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Henry Ginsberg
PCSK9 inhibitors: How do we weigh up the benefit versus cost of treatment?
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Peter Lansberg
ODYSSEY ESCAPE: a view from PCSK9 Forum
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Peter Lansberg
News: International Atherosclerosis Society consensus statement on severe familial hypercholesterolaemia
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Frederick J. Raal
Is lipoprotein(a) a cause of clinical familial hypercholesterolaemia?
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Frederick J. Raal
Peter Lansberg
Low LDL-C, PCSK9 and dementia risk?
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Frederick J. Raal
TAUSSIG: Does adding evolocumab reduce cardiovascular events in homozygous FH?
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Peter Lansberg
Changing the message on LDL cholesterol: Lifetime exposure is key
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Steve Nicholls
ESC Congress 2015 buzz: Novel LDL lowering treatments
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Peter Lansberg
Hot Topic siRNA and PCSK9
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Eric Bruckert
ODYSSEY 78 week HeFH data: Clinical perspectives
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Steve Nicholls
PCSK9 therapeutics – the next story?
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What’s next in the PCSK9 field: small interference RNA therapeutics
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Frederick J. Raal
Start treatment early: Maximise benefit
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Peter Lansberg
Dutch experience – Improving detection and care
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Steve Nicholls
How will PCSK9 inhibitors be used in practice?
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Philip Barter
New cholesterol lowering drugs in news
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Joost Besseling
Consider FH in young heart attack patients
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Sam Gidding
Making premature CHD history
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Sam Gidding
How to identify children with FH
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Albert Wiegman
Safety of lowering LDL-C
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Raul Santos
EAS Consensus Panel on Paediatric FH
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Frederick J. Raal
ISA 2015: Evolocumab in TAUSSIG homozygous FH cohort
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Henry Ginsberg
John Chapman
New era in cholesterol-lowering? PCSK9 inhibitors soon available?
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Albert Wiegman
Sam Gidding
ISA 2015: EAS Consensus Panel publishes Position Statement on Paediatric Familial Hypercholesterolaemia
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Pablo Corral
FH in Argentina: Why the European Atherosclerosis Society FH Studies Collaboration (EAS-FHSC) is key
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Erik Stroes
European Atherosclerosis Society Consensus Panel on statin-associated muscle symptoms: Professor Erik Stroes, Academic Medical Center, the Netherlands
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Henry Ginsberg
PCSK9 and Lp(a), a novel approach to a re-emergent cardiovascular risk factor
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Lluís Masana
Weighing the cost versus benefit of PCSK9-targeted therapy
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Lluís Masana
High cholesterol: an unmet need
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
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Henry Ginsberg
Looking ahead with PCSK9 Education & Research Forum
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Henry Ginsberg
What are the patient priorities for PCSK9 inhibitors?
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Steve Nicholls
Does PCSK9 inhibition impact atherosclerosis?
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Anne Tybjaerg-Hansen
Loss of function mutations in PCSK9: the trigger for therapeutic development
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
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Bertrand Cariou
Does PCSK9 have effects beyond the liver and if so, what is the evidence?
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Katherine Wilemon
Familial hypercholesterolaemia: putting the patient first
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
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Frederick J. Raal
Overlap between HoFH and severe FH and implications for evolocumab
![Play](https://www.pcsk9forum.org/wp-content/themes/pcsk9forumnew/images/play.png)
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Frederick J. Raal
Implications from TESLA for FH management
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Gerald Watts
Implications from TESLA and early TAUSSIG studies with evolocumab
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Dirk Blom
The role of PCSK9 inhibitors in FH
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Evan Stein
What are the gaps in knowledge about the PCSK9 inhibitors
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Frederick J. Raal
Do the PCSK9 monoclonal antibodies have neurocognitive effects
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Frederick J. Raal
Will the PCSK9 monoclonal antibodies replace other lipid lowering treatment used with statins
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Henry Ginsberg
New ACC/AHA guidelines for cholesterol management: View from the Editors
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Henry Ginsberg
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Evan Stein
Lowering LDL-C: How low and for how long?
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Albert Wiegman
Why is it critical to target children with FH?
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Gerald Watts
Professor Gerald Watts discusses the 10 countries project in FH
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Sam Gidding
Unmet needs in children with FH
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Jennifer Robinson
ODYSSEY long term
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Raul Santos
ODYSSEY FH and patient unmet needs
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Evan Stein
Take home messages from ACC2014
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Michel Farnier
ODYSSEY FHI FHII
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Erik Stroes
Do the PCSK9 inhibitors have pleiotropic effects?
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Alberto Zambon
ODYSSEY trials at ESC Congress Hotline
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Erik Stroes
What are the current unmet needs?
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Dirk Blom
FH issues in low to middle income regions
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Raul Santos
Improving the management of the FH patient
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Dirk Blom
The role of PCSK9 inhibitors in FH
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![Implications from TESLA and early TAUSSIG studies with evolocumab](https://img.youtube.com/vi/MCrsplQKhP4/0.jpg)
Gerald Watts
Implications from TESLA and early TAUSSIG studies with evolocumab
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Frederick J. Raal
Rationale for TESLA and results
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Evan Stein
In your opinion, what are the optimum patient populations for PCSK9 monoclonal antibody therapy?