What is PCSK9?
PCSK9 is a protein which is critically important in regulating low density lipoprotein cholesterol (LDL-C) levels by significantly increasing the clearance of LDL-C by the liver.
Clinical studies show that inhibition of PCSK9 lowers serum LDL-cholesterol levels beyond the effects of current therapies, with consistent 50-60% reductions in LDL-C levels even in patients on statin treatment.1 [ref]Tavori H, Melone M, Rashid S. Alirocumab: PCSK9 inhibitor for LDL cholesterol reduction. Expert Rev Cardiovasc Ther 2014;12:1137-44. http://www.ncbi.nlm.nih.gov/pubmed/25244623[/ref]
Potentially, PCSK9 inhibitors may allow patients at high risk of premature cardiovascular death (including those with the common genetic condition, familial hypercholesterolaemia) to achieve LDL-cholesterol targets.
What are our objectives?
The PCSK9 Education and Research Forum is increasing awareness and understanding of this exciting new development among healthcare professionals by providing free, unrestricted access to independent news, analysis and commentary from network of internationally recognised researchers and clinicians.
Additionally, it offers a wide range of expert-developed educational materials.
What is the Forum?
An independent, not-for-profit global network of healthcare professionals
Meet our Editorial Board
View all our Editorial BoardProfessor John ChapmanResearch Professor at the University of Pierre and Marie CurieProfessor Henry GinsbergDirector, Irving Institute for Clinical and Translational ResearchDr Michel FarnierClinician based at Point Medical, Dijon, France
FREE TO ALL REGISTERED HEALTHCARE PROFESSIONALS AND RESEARCHERS WORLDWIDE
What do members receive?
- Regular e-newsletters with news and analysis of clinical and scientific developments
- Expert commentaries reviewing clinical trial data on publication
- Discussions exploring the possible clinical consequences of new data
- Webinars and other interactive programmes
- Access to rapidly expanding and regularly updated educational resources including slide presentations
How to register
Register here now
|⇧1||Stein EA, Giugliano RP, Koren MJ, Raal FJ, Roth EM, Weiss R, Sullivan D, Wasserman SM, Somaratne R, Kim JB, Yang J, Liu T, Albizem M, Scott R, Sabatine MS; PROFICIO Investigators. Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies: pooled analysis of 1359 patients in four phase 2 trials. Eur Heart J 2014;35:2249-59. http://www.ncbi.nlm.nih.gov/pubmed/24598985|