VERVE-101 CRISPR gene editing treatment.
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Phase I study (reformulated) Fitzgerald K, et al. 2014.
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LIB003 is a recombinant fusion drug which combines a PCSK9-binding domain (adnectin) with human serum albumin. LIB003 is given as a monthly subcutaneous injection.
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Alirocumab is being evaluated in the ODYSSEY clinical trial programme including studies in patients with familial hypercholesterolaemia (FH), and patients with hypercholesterolaemia, including those at high cardiovascular risk.
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Evolocumab has been evaluated in the PROFICIO (Program to Reduce LDL-C and Cardiovascular Outcomes Following Inhibition of PCSK9 In Different Populations) clinical trial programme.
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Bococizumab: SPIRE clinical trial programme (terminated).
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