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Who could benefit from PCSK9 inhibitors?

Posted on 12 February 2015 |

Which patients may benefit?

Widespread use of statins in primary and secondary prevention settings, as recommended by guidelines,1 41 2 has resulted in a remarkable reduction in cardiovascular (CV) events. However, there is a substantial residual risk of fatal and non-fatal events in these populations, particularly those individuals at high risk.

These groups include:

  • Patients with familial hypercholesterolaemia (FH)
  • Patients who cannot tolerate statins
  • High CV risk patients who fail to achieve LDL cholesterol target despite high dose statin therapy

Familial hypercholesterolaemia

PlayFamilial hypercholesterolaemia: putting the patient firstPlayThe role of PCSK9 inhibitors in FHPlayDoes PCSK9 monoclonal antibody therapy have a role in homozygous FH? Henry GinsbergPlayDiscusses the 10 countries project in FH

What is familial hypercholesterolaemia (FH)?

Globally, the most common genetic condition, untreated FH is characterised by extremely high levels of atherogenic low density lipoprotein (LDL) cholesterol and a high risk of premature CV disease and death.

FH is an autosomal dominant genetic condition. Therefore, sons and daughters of a parent with FH have a 50% chance of being born with the condition.

People with FH usually have mutations in genes coding for proteins in the LDL-receptor pathway. As a result, the liver is unable to metabolise or remove excess LDL cholesterol and clear it from the body, causing high LDL cholesterol levels from birth.

More than 1,400 genetic mutations causing FH have been identified around the world. Three genes where these mutations take place are:

  • The LDL-receptor gene (LDLR) – those codes for a protein involved in remove cholesterol from the blood. This is the most common gene mutation in people with FH.
  • The PCKS9 gene (PCSK9) – this codes for an enzyme that regulates cholesterol removal by breaking down LDL receptor protein.
  • The APOB gene (APOB) – which assists binding of LDL particles.3

Types of FH

  • Heterozygous FH: This is the most common form of FH. Here, the individual has inherited a mutation in one gene from one parent and a normal gene from the other parent. If untreated, men with this condition have >50% risk of heart disease by the age of 50 and women ≥30% by the age of 60 years.4 5 6
  • Compound heterozygous FH: This occurs if a child inherits two different types of mutations in FH-causing genes from its parents. This usually leads to a more severe form of FH with higher cholesterol levels.7
  • Homozygous FH: This is rare and occurs when a child inherits the same mutation in FH-causing genes from each parent. Plasma total cholesterol levels are extremely high. Most patients with homozygous FH have clinical evidence of heart disease in childhood; sudden death from heart attack is common in childhood or adolescence.8

Most people without FH have an average total cholesterol level of 4.5-6 mmol/l (recommended <5 mmol/l). However, in people with heterozygous FH, LDL cholesterol levels can be in the range 7.5-12 mmol/l or even higher.9 People with homozygous FH may have total cholesterol levels in the range of 15-30 mmol/l.10

How common is FH?

FH is the most common genetic condition in the world. Previously, heterozygous FH was thought to affect 1 in 500 people, and homozygous FH about 1 in one million people.11

However, it is now recognised that FH is significantly under-diagnosed. Recent studies indicate that heterozygous FH may affect 1 in 200-250 people,12 13 and homozygous FH may affect as many as 1 in 160,000 to 300,000 people in Europe.14 15 16

World-wide, this means that there are an estimated 14-34 million people are living with FH.17 18

Higher frequencies of FH (up to 1 in 80 people) occur in communities where first-cousin marriages are common, and due to founder effects in certain populations such as Ashkenazi Jews, French Canadians and South African Afrikaners. 19 20

However, with a few exceptions among countries, world-wide <1% of people with FH are diagnosed.21

How effective is treatment of FH?

Marked and persistent reduction of LDL cholesterol is critically important in FH patients to reduce their very high CV risk.

However, undertreatment is a real issue. In a large study from Denmark, <50% of people with FH were on a statin.22 Untreated FH patients had a 13-fold increase in risk of a heart attack compared with those on a statin.23

Low potency statins (such as simvastatin 40 mg) are inadequate for >95% of FH patients. Most will need combination treatment, such as a potent statin plus ezetimibe, which reduces LDL cholesterol by 60-70%.24

Even among patients on combination treatment, LDL cholesterol goal attainment is problematic. In recent research from France in more than 1,500 patients with FH, <20% on maximal therapy (a potent statin which lowers LDL cholesterol by >45% and one other lipid lowering treatment), had LDL cholesterol levels <2.6 mmol/L (100 mg/dL). Importantly, 75% of FH patients with CV disease did not attain this LDL cholesterol level.25

Therefore, even on statin therapy (with or without other lipid lowering treatment), FH patients remain at high risk of CV events. In a Norwegian registry study including nearly 5,000 FH patients, FH patients died at least 15 years earlier compared with the general population. Importantly, one in 2 of FH patients died due to CV disease.26

As a result, there is a need for new therapeutic approaches which effectively reduce the very high LDL cholesterol levels occurring in these patients.

Statin intolerant patients

While most patients tolerate statin therapy, a proportion of patients with experience side effects that either prevent use or limit the dose of statin that is given.27 28 29

Statin-associated muscle symptoms (SAMS) are the most prevalent, affecting 7-29% of patients in routine practice.30 31 32 33 34 SAMS are likely to contribute to very high discontinuation rates from statins (up to 75%) within 2 years of starting treatment.35

These patients are likely to be poorly managed with current therapy, with LDL cholesterol levels typically in the region of 5.0 mmol/L (200 mg/dL) on non-statin options, including ezetimibe.36 This undoubtedly impacts CV risk, with studies showing that. CV risk is 15% higher in patients with poor adherence to statins compared with those with good adherence.37 Additionally, in elderly secondary prevention patients, poor adherence to statins can contribute to 50% higher mortality, compared with those with good adherence. 38

New approaches are needed to address this unmet clinical need.

Statin-treated patients who fail to achieve target

Despite the widespread use of statin therapy and conclusive evidence of the benefits of achieving target LDL cholesterol, <50% of patients achieve the goal set in international guidelines.39 This undoubtedly impacts CV risk, with heart attack rates of 20% within the first year.40

In these high CV risk patients, new therapeutic approaches that are more effective in reducing LDL cholesterol are clearly needed.

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References   [ + ]

PlayCould PCSK9 inhibitors be used in FH children?
Could PCSK9 inhibitors be used in FH children?
PlayStart treatment early: Maximise benefit
Start treatment early: Maximise benefit
PlayMaking premature CHD history
Making premature CHD history
PlayHow to identify children with FH
How to identify children with FH