Which patients may benefit?
Widespread use of statins in primary and secondary prevention settings, as recommended by guidelines,1 41 2 has resulted in a remarkable reduction in cardiovascular (CV) events. However, there is a substantial residual risk of fatal and non-fatal events in these populations, particularly those individuals at high risk.
These groups include:
- Patients with familial hypercholesterolaemia (FH)
- Patients who cannot tolerate statins
- High CV risk patients who fail to achieve LDL cholesterol target despite high dose statin therapy
What is familial hypercholesterolaemia (FH)?
Globally, the most common genetic condition, untreated FH is characterised by extremely high levels of atherogenic low density lipoprotein (LDL) cholesterol and a high risk of premature CV disease and death.
FH is an autosomal dominant genetic condition. Therefore, sons and daughters of a parent with FH have a 50% chance of being born with the condition.
People with FH usually have mutations in genes coding for proteins in the LDL-receptor pathway. As a result, the liver is unable to metabolise or remove excess LDL cholesterol and clear it from the body, causing high LDL cholesterol levels from birth.
More than 1,400 genetic mutations causing FH have been identified around the world. Three genes where these mutations take place are:
- The LDL-receptor gene (LDLR) – those codes for a protein involved in remove cholesterol from the blood. This is the most common gene mutation in people with FH.
- The PCKS9 gene (PCSK9) – this codes for an enzyme that regulates cholesterol removal by breaking down LDL receptor protein.
- The APOB gene (APOB) – which assists binding of LDL particles.3
Types of FH
- Heterozygous FH: This is the most common form of FH. Here, the individual has inherited a mutation in one gene from one parent and a normal gene from the other parent. If untreated, men with this condition have >50% risk of heart disease by the age of 50 and women ≥30% by the age of 60 years.4 5 6
- Compound heterozygous FH: This occurs if a child inherits two different types of mutations in FH-causing genes from its parents. This usually leads to a more severe form of FH with higher cholesterol levels.7
- Homozygous FH: This is rare and occurs when a child inherits the same mutation in FH-causing genes from each parent. Plasma total cholesterol levels are extremely high. Most patients with homozygous FH have clinical evidence of heart disease in childhood; sudden death from heart attack is common in childhood or adolescence.8
Most people without FH have an average total cholesterol level of 4.5-6 mmol/l (recommended <5 mmol/l). However, in people with heterozygous FH, LDL cholesterol levels can be in the range 7.5-12 mmol/l or even higher.9 People with homozygous FH may have total cholesterol levels in the range of 15-30 mmol/l.10
How common is FH?
FH is the most common genetic condition in the world. Previously, heterozygous FH was thought to affect 1 in 500 people, and homozygous FH about 1 in one million people.11
However, it is now recognised that FH is significantly under-diagnosed. Recent studies indicate that heterozygous FH may affect 1 in 200-250 people,12 13 and homozygous FH may affect as many as 1 in 160,000 to 300,000 people in Europe.14 15 16
World-wide, this means that there are an estimated 14-34 million people are living with FH.17 18
Higher frequencies of FH (up to 1 in 80 people) occur in communities where first-cousin marriages are common, and due to founder effects in certain populations such as Ashkenazi Jews, French Canadians and South African Afrikaners. 19 20
However, with a few exceptions among countries, world-wide <1% of people with FH are diagnosed.21
How effective is treatment of FH?
Marked and persistent reduction of LDL cholesterol is critically important in FH patients to reduce their very high CV risk.
However, undertreatment is a real issue. In a large study from Denmark, <50% of people with FH were on a statin.22 Untreated FH patients had a 13-fold increase in risk of a heart attack compared with those on a statin.23
Low potency statins (such as simvastatin 40 mg) are inadequate for >95% of FH patients. Most will need combination treatment, such as a potent statin plus ezetimibe, which reduces LDL cholesterol by 60-70%.24
Even among patients on combination treatment, LDL cholesterol goal attainment is problematic. In recent research from France in more than 1,500 patients with FH, <20% on maximal therapy (a potent statin which lowers LDL cholesterol by >45% and one other lipid lowering treatment), had LDL cholesterol levels <2.6 mmol/L (100 mg/dL). Importantly, 75% of FH patients with CV disease did not attain this LDL cholesterol level.25
Therefore, even on statin therapy (with or without other lipid lowering treatment), FH patients remain at high risk of CV events. In a Norwegian registry study including nearly 5,000 FH patients, FH patients died at least 15 years earlier compared with the general population. Importantly, one in 2 of FH patients died due to CV disease.26
As a result, there is a need for new therapeutic approaches which effectively reduce the very high LDL cholesterol levels occurring in these patients.
Statin intolerant patients
While most patients tolerate statin therapy, a proportion of patients with experience side effects that either prevent use or limit the dose of statin that is given.27 28 29
Statin-associated muscle symptoms (SAMS) are the most prevalent, affecting 7-29% of patients in routine practice.30 31 32 33 34 SAMS are likely to contribute to very high discontinuation rates from statins (up to 75%) within 2 years of starting treatment.35
These patients are likely to be poorly managed with current therapy, with LDL cholesterol levels typically in the region of 5.0 mmol/L (200 mg/dL) on non-statin options, including ezetimibe.36 This undoubtedly impacts CV risk, with studies showing that. CV risk is 15% higher in patients with poor adherence to statins compared with those with good adherence.37 Additionally, in elderly secondary prevention patients, poor adherence to statins can contribute to 50% higher mortality, compared with those with good adherence. 38
New approaches are needed to address this unmet clinical need.
Statin-treated patients who fail to achieve target
Despite the widespread use of statin therapy and conclusive evidence of the benefits of achieving target LDL cholesterol, <50% of patients achieve the goal set in international guidelines.39 This undoubtedly impacts CV risk, with heart attack rates of 20% within the first year.40
In these high CV risk patients, new therapeutic approaches that are more effective in reducing LDL cholesterol are clearly needed.
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References [ + ]
|1, 4, 11.||⇧||Reiner Z, Catapano A, De Backer G et al. ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J 2011;32:1769-1818. http://www.escardio.org/guidelines-surveys/esc-guidelines/guidelinesdocuments/guidelines-dyslipidemias-ft.pdf|
|2.||⇧||Jacobson TA, Ito MK, Maki KC, Orringer CE, Bays HE, Jones PH, McKenney JM,. Grundy SM, Gill EA, Wild RA, Wilson DP, Brown WV. National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary. J Clin Lipidol 2014;8:473-88. http://www.lipidjournal.com/article/S1933-2874(14)00274-8/pdf|
|3.||⇧||Main L. Inherited heart conditions: familial hypercholesterolaemia. British Heart Foundation/Heart UK, 2011. http://heartuk.org.uk/fh-familial-hypercholesterolemia|
|5.||⇧||NICE clinical guideline 71. Identification and management of familial hypercholesterolaemia. 2008. http://www.nice.org.uk/guidance/CG071.|
|6, 9, 12, 14, 17, 21, 24.||⇧||Nordestgaard B, Chapman MJ, Humphries SE et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. Eur J Heart J 2013; 34:3478-90a. http://www.ncbi.nlm.nih.gov/pubmed/23956253|
|7, 8, 10, 15.||⇧||Cuchel M, Bruckert E, Ginsberg HN et al. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J 2014;35:2146-57. http://www.ncbi.nlm.nih.gov/pubmed/25053660|
|13, 16, 18.||⇧||Sjouke B, Kusters DM, Kindt I et al. Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome. Eur Heart J 2014; 28 February (epub ahead of print) http://www.ncbi.nlm.nih.gov/pubmed/24585268|
|19.||⇧||Kusters DM, Huijgen R, Defesche JC et al. Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes. Neth Heart J 2011;19:175-82. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058324/|
|20.||⇧||Moorjani S, Roy M, Gagne C, et al. Homozygous familial hypercholesterolemia among French Canadians in Quebec Province. Arteriosclerosis 1989;9:211-6. http://atvb.ahajournals.org/content/9/2/211.short|
|22, 23.||⇧||Benn M, Watts GF, Tybjaerg-Hansen A, Nordestgaard BG. Familial hypercholesterolemiain the Danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication. J Clin Endocrinol Metab 2012;97:3956–64. http://www.ncbi.nlm.nih.gov/pubmed/22893714|
|25.||⇧||Béliard S, Carreau V, Carrié A, Giral P, Duchêne E, Farnier M, Ferrières J, Fredenrich A, Krempf M, Luc G, Moulin P, Bruckert E. Improvement in LDL-cholesterol levels of patients with familial hypercholesterolemia: can we do better? Analysis of results obtained during the past two decades in 1669 French subjects. Atherosclerosis 2014;234:136-41. http://www.ncbi.nlm.nih.gov/pubmed/24637413|
|26.||⇧||Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierød MB, Leren TP, Retterstøl K. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010. J Am Heart Assoc 2014;3:e001236. http://www.ncbi.nlm.nih.gov/pubmed/25468658|
|27.||⇧||Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT, Krumholz HM. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006;114:2788-97. http://www.ncbi.nlm.nih.gov/pubmed/17159064|
|28, 30.||⇧||Cohen JD, Brinton EA, Ito MK, Jacobson TA. Understanding statin use in America and gaps in patient education (USAGE): an internet-based survey of 10,138 current and former statin users. J Clin Lipidol 2012;6:208-215. http://www.ncbi.nlm.nih.gov/pubmed/22658145|
|29, 31.||⇧||Zhang H, Plutzky J, Skentzos S, Morrison F, Mar P, Shubina M, Turchin A. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med 2013;158:526-34. http://www.ncbi.nlm.nih.gov/pubmed/23546564|
|32.||⇧||Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study. Cardiovasc Drugs Ther 2005;19:403-14. http://www.ncbi.nlm.nih.gov/pubmed/16453090|
|33.||⇧||Buettner C, Rippberger MJ, Smith JK, Leveille SG, Davis RB, Mittleman MA. Statin use and musculoskeletal pain among adults with and without arthritis. Am J Med 2012;125:176-82. http://www.ncbi.nlm.nih.gov/pubmed/22269621|
|34.||⇧||El-Salem K, Ababeneh B, Rudnicki S, Malkawi A, alrefai A, Khader Y, Saadeh R, Saydam M. Prevalence and risk factors of muscle complications secondary to statins. Muscle Nerve 2011;44:877-81. http://www.ncbi.nlm.nih.gov/pubmed/22102457|
|35.||⇧||Chodick G, Shalev V, Gerber Y, Heymann AD, Silber H, Simah V, Kokia E. Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel. Clin Ther 2008;30:2167-79. http://www.ncbi.nlm.nih.gov/pubmed/19108805|
|36.||⇧||Stroes E, Colquhoun D, Sullivan D et al; GAUSS-2 Investigators. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2541-8. http://www.ncbi.nlm.nih.gov/pubmed/24694531|
|37.||⇧||Chowdhury R, Khan H, Heydon E, Shroufi A, Fahimi S, Moore C, Stricker B, Mendis S, Hofman A, Mant J, Franco OH. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur Heart J 2013;34:2940-8. http://www.ncbi.nlm.nih.gov/pubmed/23907142|
|38.||⇧||Jackevicius CA, Mamdani M, Tu JV. Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA 2002;288:462-7. http://www.ncbi.nlm.nih.gov/pubmed/12132976|
|39.||⇧||Reiner Ž, De Bacquer D, Kotseva K et al; EUROASPIRE III Study Group. Treatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III survey. Atherosclerosis 2013;231:300-7. http://www.ncbi.nlm.nih.gov/pubmed/24267243|
|40.||⇧||Jernberg T, Hasvold P, Henriksson M, Hjelm H, Thuresson M, Janzon M. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective. Eur Heart J. 2015 Jan 13. pii: ehu505. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/25586123|
|41.||⇧||Stone NJ, Robinson J, Lichtenstein AH et al. ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013 pii: S0735-1097(13)06028-2. http://content.onlinejacc.org/article.aspx?articleid=1879710|