Previous slide decks focused on landmark studies which used a monoclonal antibody approach to inhibit PCSK9. The next in this series discusses inclisiran, a small interfering RNA therapy, which prevents production of PCSK9 at its primary source in the liver.
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Weighing up STRENGTH – report and videos
Evinacumab in refractory hypercholesterolaemia
Novel PCSK9 therapies
13th Closed Virtual Meeting of the Editorial Board of PCSK9 Forum
Keynote – Post CVD event depression: The prequel and sequel
Prof. David L. Hare presents an objective overview of the evidence for depression and cardiovascular disease, taking the following questions in turn. Does depression cause cardiovascular disease? And does cardiovascular disease cause depression?
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Keynote – Lipoprotein(a): “The proof of the pudding is in the trial”
Prof. Joseph L. Witztum overviews the evolving evidence for lipoprotein(a) as a cardiovascular risk factor, culminating in the Lp(a)HORIZON outcomes study. If positive, findings from this trial will have important public health implications.
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SAMSON’s undoing is in the details
Prof. Robert S. Rosenson, Mount Sinai Icahn School of Medicine, New York, USA discusses results from the SAMSON trial of symptoms reported with statin treatment.
Other related reports:
Statin intolerance back in the news: ASCOT-LLA report argues for a nocebo effect
Read the report
Statin intolerance – 50% higher risk of recurrent heart attack in statin intolerant patients
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Adverse effects of long-term statin therapy: New statement from the EAS Consensus Panel
Read the report