News from ODYSSEY OUTCOMES: Effects of PCSK9 inhibition on total cardiovascular disease burden New US Cholesterol Guidelines: The good, the bad and the ugly Coronary artery calcium in familial hypercholesterolaemia AHA/ACC 2018 Cholesterol Guidelines also have good points Coronary artery calcium for stratifying risk in familial hypercholesterolaemia PCSK9 Forum Inhibitors and Health Economics ODYSSEY OUTCOMES Economics Study: How can we get the best value from PCSK9 inhibitors?Alirocumab safe in patients with diabetes mellitus

About the PCSK9 Education and Research Forum

PCSK9 Education and Research Forum is the independent resource on PCSK9 science and its translation into critically important new treatments to lower low density lipoprotein cholesterol (LDL-C), which promise to transform the prognosis of millions of patients with hypercholesterolaemia (cholesterol disorders), accelerated atherosclerotic vascular heart disease and a high risk of premature cardiovascular (CV) death and disability.
Aims & Objectives Mission Statement Editorial Board Partnership & Outreach Forthcoming Meetings

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AHA Scientific Sessions 2018

ODYSSEY OUTCOMES Economic Study

Novel lipoprotein(a) antisense therapy looks good

ODYSSEY OUTCOMES total events analysis

New US Cholesterol Guidelines

News from ESC Congress 2018

News from ISA 2018

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Coronary artery calcium in familial hypercholesterolaemia Lipoprotein(a) – does it matter when LDL cholesterol is low? NEW Complementary slide resources… VIDEO: New insights from ODYSSEY OUTCOMES How low should LDL cholesterol be lowered after stroke? Future dual PCSK9/GLP-1 therapy for diabetes patients? POOLED ANALYSIS Registry data gives insights into the real-world use of PCSK9 inhibitors Will CANTOS and REVEAL change how we view the clinical use of PCSK9 inhibitors? A new genetic mechanism for familial hypercholesterolaemia: PCSK9 whole gene duplication

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Coronary artery calcium in familial hypercholesterolaemia

PCSK9 Forum Inhibitors and Health Economics

The value of PCSK9 inhibition in very high risk patients is a Hot Topic in the light of recent data from the ODYSSEY OUTCOMES Economics Study. How do these data relate to the current clinical pathway used in the European setting?

PCSK9 Forum Editor Professor Anthony Wierzbicki (Guys and St. Thomas’ Hospital London, UK) puts the results in context.
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Perspective on the ODYSSEY OUTCOMES Economic Study
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PCSK9 inhibitors: How do we weigh up the benefit versus cost of treatment?
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Hot Topics

Coronary artery calcium in familial hypercholesterolaemia

Coronary artery calcium may have a role in stratifying short-term risk in patients with familial hypercholesterolaemia (FH, inherited high cholesterol), according to a new study. This noninvasive approach may have value in targeting treatment with a PCSK9 inhibitor to those patients at highest risk.

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VIDEO: Is coronary artery calcium a risk assessment too in FH?
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VIDEO: Severe FH: how to define?
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VIDEO: ESC/EAS Task Force guidance for PCSK9 inhibitors
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From the Editors

Stratifying risk in familial hypercholesterolaemia: does coronary artery calcium have a role?

According to PCSK9 Forum Editors Professor Gerald Watts (University of Western Australia, Perth, Australia) and Professor Derick Raal (University of the Witwatersrand, Johannesburg, South Africa) an expert consensus statement on the use non-invasive imaging in the care of FH patients is urgently needed.