Older ASCVD patients benefit from LDL-C lowering with evolocumab A critical appraisal of PCSK9 inhibitors: PCSK9 monoclonal antibodies versus small interfering RNA Evolocumab prevents carotid artery wall thickening in paediatric HeFH PCSK9 plays critical role in abdominal aortic aneurysm Post hoc analysis: alirocumab benefits HeFH and T3HLP patients Results from the German MILOS cohort demonstrate real-world effectiveness and safety of bempedoic acid

About the PCSK9 Education and Research Forum

PCSK9 Education and Research Forum is the independent resource on PCSK9 science and its translation into critically important new treatments to lower low density lipoprotein cholesterol (LDL-C), which promise to transform the prognosis of millions of patients with hypercholesterolaemia (cholesterol disorders), accelerated atherosclerotic vascular heart disease and a high risk of premature cardiovascular (CV) death and disability.
Aims & Objectives Mission Statement Editorial Board Partnership & Outreach Forthcoming Meetings

Question of the Month

Combination therapy in familial hypercholesterolaemia: what can we gain from novel agents?

LDL cholesterol lowering and effects on plaque: what can we learn from INTENSITY-HIGH?
Professor John Chapman

Download Now: New Slide Deck Programme

Previous slide decks focused on landmark studies which used a monoclonal antibody approach to inhibit PCSK9. The next in this series discusses inclisiran, a small interfering RNA therapy, which prevents production of PCSK9 at its primary source in the liver.

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News from the Trials

Keep up to date with latest news and analyses from PCSK9 inhibitor trials.

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Trial Resources

For expert analysis and insights

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Most viewed

ORION-8: Inclisiran shows efficacy and safety beyond six years Trial to evaluate efficacy and safety of lerodalcibep (LIB003), evolocumab and alirocumab in patients at high risk CVD (LIBerate-H2H) (NCT04790513) Apo(a) size and PAD revascularisation outcomes: What’s the link? Remembering Akira Endo and the beginning of the ‘statin era’ ANGPTL3: A cholesterol target?

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ORION-8: Inclisiran shows efficacy and safety beyond six years

Hot Topics

18th Virtual Closed Scientific Expert Meeting of the Editorial Board

Statins and PCSK9 inhibitors in combination: Initial therapy in very high-risk patients in secondary prevention
Professor Alberto Zambon proposes a novel ‘fast to target’ paradigm for patients at very high cardiovascular risk.

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From the Editors

Lerodalcibep: What does LIBerate-HeFH tell us?

Prof Derick Raal Professor Derick Raal discusses lerodalcibep data from the LIBerate-HeFH trial and explains what the results mean to practising clinicians.