Phase 2b data show benefits of oral MK-0616 in hypercholesterolaemia YELLOW III supports aggressive lipid lowering to reduce plaque progression CLEAR Outcomes shows 13% reduction in CV events with bempedoic acid Olpasiran reduces Lp(a) irrespective of baseline Lp(a)AT-TARGET-IT: Real world data show high adherence to PCSK9 inhibitors Genetic variants in PCSK9 gene not linked to heart failure

Inclisiran

ORION-1

ORION-1 Trial A placebo-controlled, double-blind, randomized trial to compare the effect of different doses of ALN-PCSSC given as single or multiple subcutaneous injections in subjects with high cardiovascular risk and elevated LDL-C Aim Primary: To evaluate the effect of ALN-PCSSC treatment on LDL-C levels at…

Posted on 11 July 2016 | Posted in Inclisiran

Prof Kausik Ray: Inclisiran, new kid on the block, looks good in ORION

Watch out PCSK9 monoclonal antibodies: inclisiran (formerly known as PCSK9si and ALN-PCSsc) has made its mark at ACC.2017. Results of the phase 2 ORION-1 trial in patients with elevated LDL cholesterol despite maximally tolerated statin therapy, showed that 2 single injections of inclisiran 300 mg…

Posted on 18 March 2017 | Posted by Kausik Ray | Posted in Videos, 66th Annual Scientific Sessions of the American College of Cardiology 2017

About PCSK9 Education and Research Forum

PCSK9 Education and Research Forum is a not-for-profit organisation established by leading researchers in the fields of atherosclerosis, lipids and cardiovascular disease. Our mission is to raise awareness and knowledge of the significant role played by PCSK9 in lipid metabolism and its value as a novel therapeutic target.

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