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Inclisiran

PlayProf Kausik Ray: Inclisiran, new kid on the block, looks good in ORION

Prof Kausik Ray: Inclisiran, new kid on the block, looks good in ORION

Watch out PCSK9 monoclonal antibodies: inclisiran (formerly known as PCSK9si and ALN-PCSsc) has made its mark at ACC.2017. Results of the phase 2 ORION-1 trial in patients with elevated LDL cholesterol despite maximally tolerated statin therapy, showed that 2 single injections of inclisiran 300 mg…

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ORION-1

ORION-1

ORION-1 Trial A placebo-controlled, double-blind, randomized trial to compare the effect of different doses of ALN-PCSSC given as single or multiple subcutaneous injections in subjects with high cardiovascular risk and elevated LDL-C  Aim Primary: To evaluate the effect of ALN-PCSSC treatment on LDL-C levels at…

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