Apo(a) size and PAD revascularisation outcomes: What’s the link?Lepodisiran: What progress towards Lp(a) reduction?Phase 1 data show sustained Lp(a) reduction with lepodisiran Heart-1 trial: Interim data show PCSK9 gene editing lowers LDL-C Small apoA isoforms linked to worse PAD revascularisation outcomes OCEAN(a)-DOSE study highlights Lp(a) variability with time

Verve-101

A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular Disease

Trial A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular Disease ClinicalTrials.gov Identifier: NCT05398029 Aim To evaluate the safety of VERVE-101 administered to patients with heterozygous familial hypercholesterolaemia (HeFH), atherosclerotic cardiovascular disease (ASCVD), and uncontrolled hypercholesterolaemia. Study design Open-label, Phase 1b, single-ascending dose…

Posted on 3 August 2022 | Posted in Trials, Verve-101

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PCSK9 Education and Research Forum is a not-for-profit organisation established by leading researchers in the fields of atherosclerosis, lipids and cardiovascular disease. Our mission is to raise awareness and knowledge of the significant role played by PCSK9 in lipid metabolism and its value as a novel therapeutic target.

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