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Statin

Managing SAMS: Will a clinical index tool aid detection?

Managing SAMS: Will a clinical index tool aid detection?

The lack of a gold standard measure has been an obstacle to the identification and management of statin-associated muscle symptoms (SAMS). However, promising data indicate that a Statin-Associated Muscle Symptom Clinical Index (SAMS-CI) may prove useful. The National Lipid Association Statin Muscle Safety Task Force…

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Managing SAMS: Most patients will tolerate a statin

Managing SAMS: Most patients will tolerate a statin

Among patients referred to a specialist centre with statin-associated muscle symptoms SAMS, most will subsequently tolerate a statin, according to this Canadian report. The authors analysed retrospective referral data from 118 patients who developed muscle-related symptoms with 2 or more statins. Over a median follow-up…

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Statin intolerance back in the news: ASCOT-LLA report argues for a nocebo effect

Statin intolerance back in the news: ASCOT-LLA report argues for a nocebo effect

Statin-associated muscle symptoms (SAMS) is very much a hot topic amongst clinical experts. The crux of the debate is differences in SAMS prevalence observed in randomized clinical trials (which showed no difference compared with placebo),1 and observational studies, which report a prevalence of up to…

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PlayHow to diagnose statin intolerance?

How to diagnose statin intolerance?

Professor Robert Rosenson (Mount Sinai Heart, Icahn School of Medicine, New York) discusses.

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Statin intolerance – 50% higher risk of recurrent heart attack in statin intolerant patients

Statin intolerance – 50% higher risk of recurrent heart attack in statin intolerant patients

Debated in the literature (1-3), statin intolerance is very much a hot topic at the moment. This new report highlights the detrimental effects on cardiovascular outcome in patients with statin intolerance. Statin-associated muscle symptoms (SAMS) are the most common clinical manifestation of statin intolerance. The…

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Updated Canadian Consensus on statin intolerance

Updated Canadian Consensus on statin intolerance

The availability of non-statin treatments that are effective in lowering LDL cholesterol and (may) also reduce cardiovascular events (ezetimibe, still be tested with the PCSK9 inhibitors) has been a key driver for new consensus on statin intolerance. Use of these nonstatin therapies offers the possibility…

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