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Homozygous FH

Evinacumab, ANGPTL3 inhibitor, awarded breakthrough status by FDA

Evinacumab, ANGPTL3 inhibitor, awarded breakthrough status by FDA

This monoclonal antibody to angiopoietin-like protein 3 (ANGPTL3), an inhibitor of lipoprotein lipase and endothelial lipase, is targeted to homozygous familial hypercholesterolaemia (FH, inherited high cholesterol), the most severe form of FH. The award of breakthrough status by the Food and Drugs Administration reflects the…

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