Familial Hypercholesterolaemia
Familial hypercholesterolaemia: putting the patient first
Patients and their families must be proactively involved in the identification and treatment of people with familial hypercholesterolaemia (FH) – a group whose severely raised low density lipoprotein cholesterol (LDL-C) puts them at a very high risk of premature death. Founder and CEO of the…
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FH is a family disorder
For every one patient there are an additional 8 cases of familial hypercholesterolaemia (FH) to be diagnosed – Katherine Wilemon, Founder, President and CEO of the FH Foundation: see http://thefhfoundation.org/ Underdiagnosis and undertreatment of FH are major issues. The clinical relevance is underlined by evidence…
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Overturning the 1%…Bridging the gaps in care
2014 FH Global Summit: 13-14 October, New York, USA: Familial hypercholesterolaemia (FH) is a major clinical challenge for the 21st century. The European Atherosclerosis Society Consensus Panel has already made the case for FH being one of the most common inherited conditions, affecting about one…
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Missing FH: How can we improve FH referral and diagnosis?
Heterozygous familial hypercholesterolemia (FH) is neither a rare disease nor a sentence to a life full of complications and early death. Recent evidence shows that even when founder effects are taken into account, heterozygous FH affects around 1/200-300 people instead of the historical estimate of…
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The role of PCSK9 inhibitors in FH
The low density lipoprotein cholesterol (LDL-C) lowering effects of evolocumab, a new PCSK9 inhibitor, in patients with familial hypercholesterolaemia (FH) are very encouraging, Dr Dirk Blom, University of Cape Town says. This will be very important in countries such as South Africa.
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Heterogeneity in FH: What are the implications for management?
According to Professor Frederick Raal, South Africa, irrespective of genotype, what matters is reducing the LDL-C burden with lipid-lowering therapy. Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder usually resulting from mutations in the LDL receptor (LDLR) gene characterised by elevated levels of LDL-cholesterol (LDL-C)…
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Rationale and Design of the Familial Hypercholesterolemia Foundation CAscade SCreening for Awareness and Detection
Familial hypercholesterolemia (FH) is a hereditary condition caused by various genetic mutations that lead to significantly elevated low-density lipoprotein cholesterol levels and resulting in a 20-fold increased lifetime risk for premature cardiovascular disease. Although its prevalence in the United States is 1 in 300 to…
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Reducing the burden of Disease and Death from Familial Hypercholesterolemia: A Call to Action
Familial hypercholesterolemia (FH) is a genetic disease characterized by substantial elevations of low-density lipoprotein cholesterol, unrelated to diet or lifestyle. Untreated FH patients have 20 times the risk of developing coronary artery disease, compared to the general population. Estimates indicate that as many as 1…
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ODYSSEY FHI FHII
Fewer than 80% of familial hypercholesterolaemia (FH) patients achieved an LDL-C level of
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