PACMAN-AMI: new data on lesion-level effects of lipid lowering AT-TARGET-IT shows reduced CV risk with early PCSK9i in ACS Real world ischaemic event reduction with PCSK9i mAbs Inclisiran role in plaque stabilisation Discontinuing PCSK9i leads to increased MACE V-MONO trial of inclisiran monotherapy meets primary endpoints

Aortic valve stenosis

PCSK9 inhibitors for aortic valve stenosis?

Aortic valve stenosis is common in the older population (>65 years), and is associated with substantial morbidity and mortality. Among those with symptoms, 5- and 10-year mortality is 50% and 90%, respectively (1). Lipids, notably lipoprotein(a) [Lp(a)] and LDL cholesterol have both been implicated in…

Posted on 14 July 2016 | Posted in News

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PCSK9 Education and Research Forum is a not-for-profit organisation established by leading researchers in the fields of atherosclerosis, lipids and cardiovascular disease. Our mission is to raise awareness and knowledge of the significant role played by PCSK9 in lipid metabolism and its value as a novel therapeutic target.

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