Videos
ODYSSEY FHI FHII
Fewer than 80% of familial hypercholesterolaemia (FH) patients achieved an LDL-C level of
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ODYSSEY trials at ESC Congress Hotline
ESC Congress 2014: Lipids Hotline: ODYSSEY TRIALS Prof Alberto Zambon, University of Padua, Italy discusses the four ODYSSEY trials with the PCSK9 inhibitor alirocumab presented at ESC Congress Hotline Sunday. Addition of a new investigational agent – Alirocumab – to high doses of statins result…
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New ACC/AHA guidelines for cholesterol management: View from the Editors
Should low density lipoprotein cholesterol (LDL-C) targets have been dropped from guidelines? Probably not argues Professor Henry Ginsberg, Co-editor of the PCSK9 Forum.
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Implications from TESLA and early TAUSSIG studies with evolocumab
Results of clinical trials of the investigational therapy – evolocumab, a PCSK9 inhibitor will potentially change care of patients at a high risk of cardiovascular disease (heart attacks), by reducing their very high low density lipoprotein cholesterol (LDL-C) levels. The Forum talks to Professor Gerald…
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FH issues in low to middle income regions
Despite the availability of statins, treatment of familial hypercholesterolaemia (FH) is a significant issue with a high unmet need in a middle-income country, according to Dr Dirk Blom of Cape Town, South Africa. As a result, new novel therapies are urgently needed.
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Rationale for TESLA and results
Low density lipoprotein cholesterol (LDL-C) can be significantly reduced in patients with a serious genetic disorder – homozygous familial hypercholesterolaemia (FH) – when a PCSK9 inhibitor evolocumab is added to statins and other lipid-lowering medications. Professor Frederick Raal explains the results of the TESLA study.
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Overlap between HoFH and severe FH and implications for evolocumab
The implications of the overlap between homozygous hypercholesterolaemia and severe familial hypercholesterolaemia (FH) – two genetic disorders characterised by very high levels of low density lipoprotein cholesterol (LDL-C) – should be considered when selecting treatment. Professor Frederick Raal discusses the issue.
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Why is it critical to target children with FH?
Familial hypercholesterolaemia (FH) is the most common genetic disorder in the world. People with FH have high levels of low density lipoprotein cholesterol (LDL-C) resulting in a high risk of premature and sudden death. Now early diagnosis and treatment can save lives, says Dr Albert…
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Professor Gerald Watts discusses the 10 countries project in FH
The International Atherosclerosis Society has begun a study in Asia and the Pacific Rim to provide the first comprehensive investigation of the worlds commonest genetic disorder, familial hypercholesterolaemia (FH) in the region. FH results in very high levels of low density lipoprotein cholesterol (LDL-C) and…
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What are the current unmet needs?
Despite statins, there are significantly unmet clinical needs in cholesterol lowering treatment. Statin do not effectively treat more than 50% of people with Familial Hypercholesterolaemia (FH) and other patients have intolerable side effects, says Professor Erik Stroes.
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PCSK9 and Lp(a), a novel approach to a re-emergent cardiovascular risk factor
New disclosures show that inhibition of PCSK9 reduces Lp(a) cholesterol – an emerging risk factor for cardiovascular disease, according to US expert, Professor Henry Ginsberg.
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Implications from TESLA for FH management
The investigational PCSK9 inhibitor evolocumab, promises to be an important new treatment for a rare but serious genetic disorder, homozygous familial hypercholesterolaemia, according to one of the investigators in the TESLA study, Professor Frederick Raal.
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Do the PCSK9 monoclonal antibodies have neurocognitive effects
There is reassuring evidence of the neurocognitive safety of the monoclonal antibodies developed to reduce low density lipoprotein cholesterol (LDL-C) by targeting PCSK9, Professor Frederick Raal discusses this topic.
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Unmet needs in children with FH
Identification and treatment to reduce low density lipoprotein cholesterol (LDL-C) of children with familial hypercholesterolaemia (FH) is vital to reduce the risk of cardiovascular death in early adulthood. FH is the most common genetic disorder in the world. Parents and healthcare professionals need to be…
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ODYSSEY long term
Low density lipoprotein cholesterol (LDL-C) was reduced by 60% in patients treated an investigational PCSK9 inhibitor, Alirocumab in addition to statin therapy, for about 52 weeks in the ODYSSEY study. The lead investigator, Professor Jennifer Robinson discusses how this was translated into a reduction in…
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Improving the management of the FH patient
Professor Raul Santos from Brazil says that the new therapies which inhibit PCSK9 to significantly reduce low density Lipoprotein Cholesterol (LDL-C) when given in addition to other cholesterol lowering drugs offer a very important advance in reducing cardiovascular risk in people with Familial Hypercholesterolemia (FH).
read more »Implications from TESLA and early TAUSSIG studies with evolocumab
Results of clinical trials of the investigational therapy – evolocumab, a PCSK9 inhibitor will potentially change care of patients at a high risk of cardiovascular disease (heart attacks), by reducing their very high low density lipoprotein cholesterol (LDL-C) levels.
read more »
In your opinion, what are the optimum patient populations for PCSK9 monoclonal antibody therapy?
PCSK9 monoclonal antibodies offer very important new treatments to lowed low density lipoprotein cholesterol (LDL-C) in patients who cannot tolerate statins or whose LDL-C is inadequately reduced as well as those people with high LDL-C caused by Familial Hypercholesterolemia.
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Weighing the cost versus benefit of PCSK9-targeted therapy
PCSK9 inhibitors are the most important advance in cholesterol lowering treatments since the discovery of statin drugs, says Spanish vascular disease researcher, Professor Lluís Masana.
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High cholesterol: an unmet need
Health authorities are failing to recognise that most patients do not achieve the cholesterol levels needed to prevent cardiovascular disease. Professor Lluís Masana says this must become a public health priority.
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