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PCSK9 inhibition reduces atherosclerosis development

Exciting results from an animal study show that a monoclonal antibody to PCSK9, alirocumab, reduces atherosclerosis development. This study used an experimental model of dyslipidaemia and atherosclerosis (APOE*3Leiden.CETP mice) fed a Western-type diet. The mice were treated with alirocumab (3 or 10 mg/kg, weekly subcutaneous…

Predicting the PCSK9 response to statin treatment

Targeted next generation sequencing improves FH diagnosis

ACC 2014 Alirocumab: One-year data in heterozygous FH

Treatment with the PCSK9 monoclonal antibody alirocumab 150 mg every 2 weeks, in addition to statin±ezetimibe,  resulted in substantial LDL-C reductions in patients with heterozygous FH, consistent with phase II trial data, which were sustained over 12 months. These data extend the evidence for the…

JUPITER Lp(a) analysis and residual CV risk

This analysis from the JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin) in individuals with low LDL cholesterol and elevated high-sensivity C-reactive protein levels suggests that elevated Lp(a) is a contributor to lipid-related residual CV risk. The study…

New ACC/AHA guidelines for cholesterol management: View from the Editors