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News from AHA Scientific Sessions
13-15 November 2021

Hope for an oral PCSK9 inhibitor?
Early data for MK-0616 are encouraging.
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Long-term data with evinacumab in homozygous familial hypercholesterolaemia (FH)
This novel ANGPTL3-directed therapy was effective and well tolerated in the longer-term in adults and adolescents with homozygous FH on aggressive lipid lowering therapy.
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Alirocumab plus evinacumab treatment in homozygous FH
This combination reduced LDL cholesterol levels by more than 60%.
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More insights from ORION
The efficacy of inclisiran is not influenced by baseline glycaemic status or body mass index.
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Question of the month
Derick Raal
Will evinacumab eliminate the need for LDL-apheresis in patients with homozygous FH?

Professor Derick Raal (University of the Witwatersrand, Johannesburg, South Africa) gives his view.
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