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Stratifying cardiovascular risk in familial hypercholesterolaemia

People with familial hypercholesterolaemia (FH, inherited high cholesterol) are at high risk for atherosclerotic cardiovascular disease, especially if untreated or initiation of lipid-lowering therapy is delayed. But the level of risk is not the same in all individuals. A key question for clinicians is how to identify those who would clearly benefit from treatment with a PCSK9 inhibitor.


Professor Raul Santos(Hospital Israelita Albert Einstein and University of São Paulo, Brazil) discusses results from a cohort study proposing coronary artery calcium score as a risk tool.

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WattsRaalIn the latest Editors’ Corner, Professor Gerald Watts (University of Western Australia, Perth, Australia) and Professor Derick Raal (University of the Witwatersrand, Johannesburg, South Africa) weigh up the evidence – and the outstanding questions.

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What is clear, is that an expert consensus statement on the use of coronary artery calcium score and non-invasive imaging in the care of FH, taking account of health economics, is urgently needed.

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