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Latest News from the 7th Expert Meeting of PCSK9 Forum, Barcelona, Spain

Intracellular actions of PCSK9

The hepatic extracellular function of PCSK9 in inhibiting the LDL receptor is now well established. With the development of novel agents that block PCSK9 synthesis upstream, investigation of intracellular actions of PCSK9 is a new focus of interest.

Dr Jan Albert Kuivenhoven (University of Groningen, University Medical Center Groningen, The Netherlands) overviews the evidence for intracellular actions of PCSK9.
Intracellular actions of PCSK9

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PCSK9 and the beta-cell

PCSK9 is expressed in human pancreatic islets, where it down-regulates LDL receptor expression. But what are the effects of PCSK9-deficiency on glucose homeostasis and insulin secretion?

Dr Bertrand Cariou (l'Institut du Thorax Université de Nantes, France) overviews the evidence from studies to date.
PCSK9 and the beta-cell

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Other links

Video: Dr Bertrand Cariou discusses the potential implications of intracellular inhibition of PCSK9

Video: More from FOURIER: PCSK9 Forum Editor Professor John Chapman discusses the implications of a new analysis in subjects with very low LDL-C levels

News: More from FOURIER: Evolocumab is as effective in diabetic and nondiabetic patients, with no impact on glucose control

News: ODYSSEY DM-Insulin: Alirocumab reduces LDL-C in insulin-treated diabetes regardless of diabetes type; study now published
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