Home  |  About  |  PCSK9  |  News  |  Commentary  |  Trials  |  Videos  |  Resources  |  Contact Latest News from the 7th Expert Meeting of PCSK9 Forum, Barcelona, Spain Intracellular actions of PCSK9 The hepatic extracellular function of PCSK9 in inhibiting the LDL receptor is now well established. With the development of novel agents that block PCSK9 synthesis upstream, investigation of intracellular actions of PCSK9 is a new focus of interest. Dr Jan Albert Kuivenhoven (University of Groningen, University Medical Center Groningen, The Netherlands) overviews the evidence for intracellular actions of PCSK9. Watch the presentation » PCSK9 and the beta-cell   PCSK9 is expressed in human pancreatic islets, where it down-regulates LDL receptor expression. But what are the effects of PCSK9-deficiency on glucose homeostasis and insulin secretion? Dr Bertrand Cariou (l'Institut du Thorax Université de Nantes, France) overviews the evidence from studies to date. Watch the presentation » Other links Video: Dr Bertrand Cariou discusses the potential implications of intracellular inhibition of PCSK9 Video: More from FOURIER: PCSK9 Forum Editor Professor John Chapman discusses the implications of a new analysis in subjects with very low LDL-C levels News: More from FOURIER: Evolocumab is as effective in diabetic and nondiabetic patients, with no impact on glucose control News: ODYSSEY DM-Insulin: Alirocumab reduces LDL-C in insulin-treated diabetes regardless of diabetes type; study now published Check back for the latest news and views about PCSK9 science and translation to the clinic Like us on Facebook For the latest updates, PCSK9 news and analysis. Follow us on Twitter Hot topics, news and conference reports. YouTube Channel For videos, interviews and webcasts from leading experts. Our popular therapeutic guide Read online & download second edition now » Register now at www.pcsk9forum.org to receive the updated third edition e-book with post ACC17 content including the FOURIER trial. Questions & Answers Read the full answer and other questions on the PCSK9 Forum » Educational Partners and Supporters Copyright PCSK9 Forum 2017. Please click here to unsubscribe from future mailings.